1.What is the dbPepNeo?

dbPepNeo is a manually curated database, which collected experimentally supported human leukocyte antigen class I (HLA-I) binding neoantigens. It not only contains precious mass spectrometry-associated HLA-I binding neoantigens, but also added the up-to-date immunogenic neoantigens verified by specific T-cell response experiments.

2.How to search the neoantigens?

3.How to predict the neoantigens?

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6.Abbreviations.

LC: low confidence
MC: medium confidence
HC: high confidence
Cancer: cancer type
Gene: gene name
HLA allele: HLA allele
Mut peptide: mutated peptide sequence
Mut affinity (nM): mutated peptide affinity IC50 (nM), the predicted binding affinity between mutant peptide and HLA allele by NetMHCpan (v4.0).
Mut %Rank: %Rank of mutated peptide, the predicted binding affinity between mutant peptide and HLA allele by NetMHCpan (v4.0).
Mut binding level: binding level between mutant peptide and HLA allele. Scoring criteria: Rank% < 0.5 define as strong binding, denoted as ‘SB’; 0.5< Rank% <2 define as weak binding, denoted as ‘WB’; Rank% >2 define as nonbinding, denoted as ‘NB’.
WT peptide: wild type peptide sequence
Peptide length: the number of amino acids contained in the peptide
Mutation: amino acid change
Verification: method of experimental verification
Reference: the supporting literature links
“/”: information not provided in the original article is marked as “/”